Abstract
Background Dyslipidemia and central obesity are the main components of metabolic syndrome (MS), which represent important risk factors for cardiovascular diseases in people living with HIV. The lipid accumulation product (LAP) index has been shown in studies as an efficient marker of MS in general adult population and its applicability in HIV-infected population is not discussed. We aimed to assess the accuracy of the LAP index to identify MS in people living with HIV.
Methods It is a cross-sectional study with 141 HIV-infected patients on antiretroviral therapy, conducted in a reference centre of infectious diseases in southeast Brazil. Evaluations included LAP index, anthropometric measurements and clinical and laboratorial variables. MS was defined by International Diabetes Federation (IDF) criteria.
Results The prevalence of MS in our sample was 10.6%. A positive and significant correlation was found between the MS and LAP (r=0.401; p<0.01), MS and body mass index (r=0.361; p<0.01) and MS and waist circumference (r=0.427; p<0.01) in our sample. The analysis of the receiver-operating characteristic (ROC) curve revealed that the best cut-off value for LAP index to define MS was 59.4 (sensitivity 80%, specificity 79% and area under the curve (AUC) of 0.875. In female and male, analysis of the ROC curve revealed that the best cut-off value for LAP index to define MS was 56.3 (sensitivity 100%, specificity 82% and AUC of 0.929) and 52.0 (sensitivity 78%, specificity 74% and AUC of 0.838), respectively.
Conclusion Despite the low prevalence of MS in our sample, the ROC curves analyzes demonstrated a good diagnostic accuracy as an additional screening tool of MS according to the IDF.
- Received June 7, 2019.
- Revision received January 15, 2020.
- Accepted March 13, 2020.
