Abstract
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12 year-old, athletic male with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.
Footnotes
Insitution at which the work was performed: Paediatric Respiratory Deparment, National Children’s Hospital, Dublin 24, Ireland.
- Received March 16, 2016.
- Revision received August 2, 2016.
- Accepted September 6, 2016.
