Thyrotoxic Periodic Paralysis: A Case Report and Literature Review

  • Clinical Medicine & Research
  • July 2009,
  • cmr.2009.816;
  • DOI: https://doi.org/10.3121/cmr.2009.816

Abstract

We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. Hypokalemia was documented in one episode and managed with intravenous potassium chloride. Hyperthyroidism was diagnosed 4 months after onset of attacks because of mild symptoms. The patient was subsequently diagnosed as having thyrotoxic periodic paralysis associated with Graves′ disease. Treatment with propranolol and methimazol was initiated and 1 year later he remains euthyroid and symptoms free. Thyrotoxic periodic paralysis is a rare disorder, especially among Caucasians, but it should always be considered in patients with acute paralysis and hypokalemia, and thyroid function should be evaluated.

  • Received August 25, 2008.
  • Revision received January 6, 2009.
  • Accepted January 30, 2009.
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