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ON THE COVER: Artistic interpretation of a human skeletal structure highlighting the ribs, scapula, and humerus. Original art by Tamara A. Kronenwetter-Koepel. Copyright 2005 Marshfield Clinic. See related articles in this issue: In "A Case of Gorham's Disease With Chylothorax Treated Curatively With Radiation Therapy" (pp. 83–86), Duffy and colleagues present an interesting case of a rare disease that cause's massive osteolysis. Gorham's disease results when lymphatic and vascular capillaries infiltrate bone causing resorption of osseous tissue and replacement with angiomatous tissue giving the appearance of missing bone on X-ray imaging. Dr. Dipak V. Patel provides an extensive clinical overview of "Gorham's Disease or Massive Osteolysis" (pp. 65–74). Dr. Patel highlights the historic background and discusses the etiopathology, clinical presentation, methods for diagnosis, and treatment optionsfor this intriguing and extremely rare disease.