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ON THE COVER:

Flu viruses. Conceptual image of influenza viruses (brown) in the airways of the lung. The virus particles are not at the same scale as the lung cilia (blue). Each virus consists of a core of RNA (ribonucleic acid) genetic material surrounded by a protein coat (brown). Embedded in the coat are surface proteins (spikes). There are two types of surface protein, hemagglutinin and neuraminidase, and each exists in several subtypes. Both surface proteins are associated with the pathogenicity of a virus. Hemagglutinin binds to host cells, allowing the virus to enter them and replicate. Neuraminidase allows the new particles to exit the host after replication.

Image by Karsten Schneider / Photo Researchers, Inc. Image and text copyright 2012 Photo Researchers, Inc. All Rights Reserved.

See related article:

“Comparison of Nasal and Nasopharyngeal Swabs for Influenza Detection in Adults” pp. 215–218.