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This Article Full Text Full Text (PDF) All Versions of this Article: cmr.2007.751v1 5/4/210    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Ogunmodede, F. Articles by Evans, A. C. PubMed PubMed Citation Articles by Ogunmodede, F. Articles by Evans, A. C.

Human Papillomavirus Infections in Primary Care

Folashade Ogunmodede, MD, Department of Internal Medicine, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, Wisconsin 54449
Steven H. Yale, MD, Department of Internal Medicine, Marshfield Clinic, and Clinical Research Center Marshfield Clinic Research Foundation, 1000 N. Oak Avenue, Marshfield, Wisconsin 54449
Bruce Krawisz, MD, Department of Pathology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, Wisconsin 54449
Gregory C. Tyler, MD, Department of Obstetrics and Gynecology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, Wisconsin 54449
Anthony C. Evans, MD, PhD, Division of Gynecologic Oncology, University of Wisconsin, 600 Highland Avenue, H4/636, Madison, Wisconsin 53792

Reprint Requests: Folashade Ogunmodede, MD, Department of Internal Medicine, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, Tel: 715-387-5537, Fax: 715-389-3808, Email: ogunmodede.folashade{at}marshfieldclinic.org

Cervical cancer continues to be a leading cause of mortality worldwide. The incidence and mortality associated with invasive cervical cancer have declined significantly in developed countries due to widespread availability of screening with the Papanicolaou (Pap) test. However, the incidence and prevalence of non-invasive cervical intraepithelial neoplasms and genital warts related to oncogenic and nononcogenic strains of human papilloma viruses (HPV) have remained relatively stable. Recent advances in molecular diagnostics have resulted in improved characterization of various HPV types and have led to changes in terminology of Pap test findings. Changes in nomenclature may lead to confusion among primary care providers regarding how best to further evaluate abnormal cytological results. This article provides a concise overview of the approach to the treatment of genital warts and management of abnormal cervical cytology based on guidelines from the American Society of Colposcopy and Cervical Pathology. It also reviews advances in HPV vaccine development and the new recombinant vaccine recently approved for use in the United States.

Key Words: Genital warts • HPV • Pap test