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Advancements in the Diagnosis and Treatment of Differentiated Thyroid Cancer

Pennsylvania State University College of Medicine Hershey, Pennsylvania

REPRINT REQUESTS: Brendan C. Stack, Jr., MD, FACS, Director of Head and Neck, Oncology/Reconstruction, Pennsylvania State University, College of Medicine, 500 University Ave, H091, Hershey, PA 17033-0850, Email: bstack{at}psu.edu

[See related article: 53–56]

Key Words: Iodine radioisotopes • Radioguided surgery • Thyroid neoplasms • Radiotherapy

The article, "Recombinant TSH-Stimulated, Radioguided Differentiated Thyroid Carcinoma Surgery," highlights two recent advancements in the diagnosis and treatment of well-differentiated thyroid cancer. The first is the use of thyrogen to stimulate the uptake of ¹³¹I in thyroid remnants and/or metastases without induction of a clinical hypothyroid state. Secondly, is the use of an intraoperative gamma detector to find and confirm removal of remnant thyroid tissue with radionuclide uptake.

Thyrogen is now widely used to conduct surveillance scanning in thyroid cancer patients. Gamma probe localization is used for sentinel node identification for breast, lung, and head and neck malignancies, as well as melanoma, and minimally invasive parathyroidectomy. The unique aspect of this report is that the two principles have been united, probably for the first time.

Although these results are quite preliminary, they serve to illustrate that an increased ability to biochemically manipulate and image tissues will potentially enable improved staging and treatment for iodine avid thyroid disease, whether in its primary presentation or in the setting of recurrence. Prospective clinical trials will be required to confirm these initial impressions.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stack, B. C. Search for Related Content PubMed PubMed Citation Articles by Stack, B. C., Jr.