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Clinical Medicine & Research
Volume 4, Number 4 : 310 -321
doi:
© 2006 Marshfield Clinic
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Review

Lupus and Pregnancy: Complex Yet Manageable

Josephine Patricia Dhar, MD and Robert J. Sokol, MD

Josephine Patricia Dhar, MD, Assistant Professor of Medicine, Internal Medicine/Rheumatology, Wayne State University School of Medicine, Detroit, Michigan USA
Robert J Sokol, MD, Director, C.S. Mott Center for Human Growth and Development, Distinguished Professor of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan USA

Reprint Requests: Josephine Patricia Dhar, MD, Harper University Hospital, 6 Hudson, Mailbox in Gastroenterology Area, 3990 John R, Detroit, MI 48201 USA, Email: PDhar{at}med.wayne.edu

Systemic lupus erythematosus is a chronic multi-system autoimmune disease that occurs predominantly in women of childbearing age. The risk of complications and adverse fetal outcomes in pregnant women with lupus is high. Moreover, pregnancy can cause flares of lupus disease activity necessitating maternal immunosuppressive intervention. Interestingly, many potential complications of pregnancy present as symptoms of lupus making diagnosis and treatment a challenge.Advancing technology and better understanding of the maternal-fetal dyad in lupus have improved outcomes in lupus pregnancies over the last 40 years. This article will briefly review the important issues in pregnancies complicated by lupus and provide a general guideline to physicians for monitoring and treatment.

Key Words: Fetal outcomes • Lupus • Maternal outcomes • Pregnancy • Systemic lupus erythematosus






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