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Cytokines and Chemokines in Uveitis – Is there a Correlation with Clinical Phenotype?

Kenneth G.-J. Ooi, MSurg, MBBS, Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
Grazyna Galatowicz, BSc, Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
Virginia L. Calder, PhD, Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
Susan L. Lightman, PhD, FRCP, FRCOphth, FRCP(Ed), FMedSci, Department of Clinical Ophthalmology, Moorfields Eye Hospital, London, United Kingdom

Reprint Requests: Susan L. Lightman, PhD, Department of Clinical Ophthalmology, Moorfields Eye Hospital, City Rd, London, UK EC1V 2PD, Tel.: 44-20-7566-2266, Fax: 44-20-7251-9350, Email: s.lightman{at}ucl.ac.uk

Uveitis is a general term for intraocular inflammation and includes a large number of clinical phenotypes. As a group of disorders, it is responsible for 10% of all registered blind patients under the age of 65 years. Immune-mediated uveitis may be associated with a systemic disease or may be localized to the eye. The pro-inflammatory cytokines interleukin (IL)-1ß, IL-2, IL-6, interferon- and tumor necrosis factor- have all been detected within the ocular fluids or tissues in the inflamed eye together with others, such as IL-4, IL-5, IL-10 and transforming growth factor-ß. The chemokines IL-8, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1, MIP-1ß and fractalkine are also thought to be involved in the associated inflammatory response. There have been a number of studies in recent years investigating cytokine profiles in different forms of uveitis with a view to determining what cytokines are important in the inflamed eye. This review attempts to present the current state of knowledge from in vitro and in vivo research on the inflammatory cytokines in intraocular inflammatory diseases.

Key Words: Ankylosing spondylitis • Aqueous humor • Behçet’s disease • Chemokines • Cytokines • Fuch’s heterochromic cyclitis • Multiplex • Sarcoidosis • Uveitis • Vogt-Koyanagi-Harada disease

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				J.A.M. van Laar and P.M. van Hagen Cytokines in Uveitis Clin. Med. Res., December 1, 2006; 4(4): 248 - 249. [Full Text] [PDF]