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Clinical Medicine & Research
Volume 4, Number 4 : 250 -255
doi:
© 2006 Marshfield Clinic
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Short Communication of Original Research

Innate Immunity SNPs are Associated with Risk for Severe Sepsis after Burn Injury

Robert C. Barber, PhD, Ling-Yu E. Chang, BS, Brett D. Arnoldo, MD, Gary F. Purdue, MD, John L. Hunt, MD, Jureta W. Horton, PhD and Corinne C. Aragaki, PhD

Robert C. Barber, PhD, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
Ling-Yu E. Chang, BS, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
Brett D. Arnoldo, MD, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
Gary F. Purdue, MD, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
John L. Hunt, MD, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
Jureta W. Horton, PhD, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas USA
Corinne C. Aragaki, PhD, Divisions of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, Texas USA

Reprint Requests: Robert C. Barber, PhD, University of Texas Southwestern Medical Center, Department of Surgery, 5323 Harry Hines Blvd., Dallas, TX 75390-9160, Tel.: 214-648-8043, Fax: 214-648-8420, Email: robert.barber{at}utsouthwestern.edu

Abstract

Objective: To analyze allelic association with clinical outcome in a cohort of burn patients.

Patients: Two hundred twenty-eight individuals with burns ≥15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One hundred fifty-nine of these patients were analyzed previously.

Methods: Candidate polymorphisms within interleukin-1 beta (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-{alpha}), cellular differentiation marker 14 (CD14) and toll-like receptor 4 (TLR4) were evaluated by logistic regression analysis for association with increased risk for severe sepsis (sepsis plus organ dysfunction or shock).

Results: After adjustment for age, burn size, ethnicity, gender and inhalation injury, alleles at TNF-{alpha} (308G, p=0.013), TLR4 (+896G, p=0.027), IL-6 (174C, p=0.040) and CD14 (159C, p=0.047) were significantly associated with an increased risk for severe sepsis.

Conclusions: Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.

Key Words: Allelic association • Burns • CD14 • IL-6 • Polymorphism • Sepsis • SNP • TLR4 • TNF-{alpha}






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