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Clinical Medicine & Research
Volume 4, Number 1 : 7 -11
doi:10.3121/cmr.4.1.7
© 2006 Marshfield Clinic
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Original Research

Imbalanced Distribution of Plasmodium falciparum EBA-175 Genotypes Related to Clinical Status in Children from Bakoumba, Gabon

Fousseyni S. Touré, PhD, C. Bisseye and Elie Mavoungou, PhD

Fousseyni S. Touré, PhD, Centre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon.
C. Bisseye, PhD student, Centre International de Recherches Médicales de Franceville, BP 769 Franceville, Gabon.
Elie Mavoungou, PhD, Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon and Institute for Tropical Medicine, Department of Parasitology, University of Tübingen, Germany.

Reprint Requests: Dr. E. Mavoungou, PhD; Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; c/o Institute for Tropical Medicine, Department of Parasitology, University of Tübingen, Wilhelmstrasse 27, 72074 Tübingen, Germany; Tel: 7071/298 21 94; Fax: 7071/29 58; Email: elie.mavoungou{at}uni-tuebingen.de

Objective: The erythrocyte binding antigen 175 kDa (EBA-175) of Plasmodium falciparum is one of the major ligands for red blood cell invasion by merozoites. EBA-175 is a dimorphic antigen but the role that dimorphism plays in host parasite interaction is not fully understood. In this study, we sought to determine the distribution of EBA-175 genotypes and its pathogenetic influence.

Methods: The nested polymerase chain reaction was used to determine the genotypes of P. falciparum isolates from asymptomatic and symptomatic Gabonese children.

Results: CAMP strains (C-segment) and FCR-3 strains (F-segment) were found in 13/50 (26%) and 19/50 (38%) symptomatic children, respectively and in 16/66 (24%) and 46/66 (70%) asymptomatic children, respectively. The prevalence of mixed C-/F- infection was 18/50 (36%) and 4/66 (6%) in symptomatic and asymptomatic children, respectively.

Conclusions: These results show that mixed C-/F- infection is associated with clinical malaria ({chi}2, P <0.01) and may have important therapeutic implications.

Key Words: CAMP strains • Erythrocyte binding antigen 175 kDa • FCR-3 strains • Plasmodium falciparum




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