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Accuracy of Noninvasive Ejection Fraction Measurement in a Large Community-Based Clinic

Dana E. Habash-Bseiso, MD, Department of Internal Medicine, Marshfield Clinic, Marshfield, Wisconsin 54449
Roxann Rokey, MD, Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449
Charles J. Berger, BS and Andrew W. Weier, MA, Clinical Data Registries, Marshfield Clinic, Marshfield, Wisconsin 54449
Po-Huang Chyou, PhD, Biostatistics and Bioinformatics Core, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449

Reprint Requests: Roxann Rokey, MD, Department of Cardiology, Marshfield Clinic, 1000 North Oak Avenue, Marshfield,WI 54449,Tel: 715-387-5080, Fax: 715-389-3808, Email: rokey.roxann{at}marshfieldclinic.org

Objective: Compare the agreement of two dimensional echocardiography (echocardiography) and electrocardiogram (ECG)-gated single photon emission computed tomography (SPECT), with left ventricular contrast angiography (angiography) for the evaluation of left ventricular ejection fraction (LVEF).

Design: Retrospective cohort study.

Data Source: American College of Cardiology National Cardiovascular Data Registry^TM (ACC-NCDR).

Participants: Patients from a large, community-based clinic in central Wisconsin.

Methods: Consecutive patients (1999–2002) were identified from the ACC-NCDR dataset who underwent angiography and echocardiography or SPECT within 1 month of each other for evaluation of LVEF. Noninvasive LVEF values were compared to those obtained by angiography using the paired t-test. Regression analysis was used to assess the relation between the compared methods. Bland-Altman analyses were performed to assess the agreement between LVEF values obtained by the noninvasive techniques and angiography. Sensitivity and specificity of detecting depressed LVEF were determined for noninvasive techniques. Regression equations were determined for estimating angiographic values from the echocardiographic or SPECT values.

Results: Five hundred thirty-four patients underwent 542 angiographic studies: SPECT in all 534 patients, combined SPECT and echocardiographic studies in 201 patients, and combined angiographic and echocardiographic studies in 202 patients. Correlation of angiographic LVEFs with both echocardiographic and SPECT LVEFs was significant (r = 0.70 and r = 0.69, respectively; p<0.0001). Echocardiographic LVEFs were lower than those determined by angiography (49% ± 1.0% versus 54% ± 1.0%;p<0.0001). SPECT LVEFs were also lower than angiographic LVEFs (49% ± 0.6% versus 57% ± 0.6%; p<0.0001). For 201 patients who underwent both SPECT and echocardiography, SPECT LVEFs were lower (47% ± 1.0% for SPECT versus 49% ± 1.0% for echocardiography; p<0.05). Bland-Altman analysis revealed widely varying differences between techniques with broad confidence intervals. Nonetheless, sensitivity and specificity for determining LVEFs of <40% for SPECT and echocardiography were 90% and 86%, and 75% and 89%, respectively. LVEF of 35% was correctly assessed by both SPECT and echocardiography. Sensitivity and specificity for SPECT were 82% and 89%, and 81% and 88% for echocardiography.

Conclusion: At our institution, LVEFs obtained noninvasively by echocardiography or SPECT are lower than angiographic LVEFs with widely fluctuating differences. Regression equations can be used to correct the noninvasive readings. Although lower, noninvasive techniques appear to accurately assess depressed LVEFs (<40% and <35%). The accuracy of noninvasive techniques for the evaluation of LVEF should be considered when managing and determining prognoses of patients with cardiac conditions. Individual institutions should determine the validity of the noninvasive techniques they use to assess LVEF

Key Words: Left ventricular dysfunction • Echocardiography • Single-photon emission-computed tomography • Angiography

This article has been cited by other articles:

				T. Tak Ejection Fraction Derived by Noninvasive Modalities Versus Left Ventricular Angiographic Determination Clin. Med. Res., May 1, 2005; 3(2): 61 - 62. [Full Text] [PDF]