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Cyclooxygenase-2 Inhibitors in Gynecologic Practice

Department of Obstetrics and Gynecology, Marshfield Clinic-Wausau Center, Wausau, Wisconsin

REPRINT REQUESTS: Thomas P. Connolly, DO, Department of Obstetrics and Gynecology, Marshfield Clinic-Wausau Center, 2727 Plaza Drive, Wausau, WI 54401, Telephone: 715-847-3191, Fax: 715-389-3808, Email: connolly.thomas{at}mashfieldclinic.org

Treatment of pain and inflammation associated with dysmenorrhea, endometriosis, ovarian cancers and operative procedures is an ongoing challenge in gynecology. Understanding the roles of prostanoids and estrogen in these conditions and appropriate treatment approaches have advanced beyond traditional nonsteroidal anti-inflammatory drugs. In this article, the author describes some of the basic mechanisms of nonspecific nonsteroidal anti-inflammatory drugs and newer cyclooxygenase-2 inhibitors, especially as they are used in the obstetrics/gynecology practice.

Key Words: Nonsteroidal anti-inflammatory drugs • Cyclooxygenase inhibitors • Endometriosis • Dysmenorrhea • Ovarian cancer • Perioperative pain • Inflammation

This article has been cited by other articles:

				C.K.S. Ong, P. Lirk, C.H. Tan, and R.A. Seymour An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs Clin. Med. Res., March 1, 2007; 5(1): 19 - 34. [Abstract] [Full Text] [PDF]