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Genetics of Prostate Cancer

Personalized Medicine Research Center, Marshfield Medical Research Foundation, Marshfield, Wisconsin

Sherry A. Salzman

Personalized Medicine Research Center, Marshfield Medical Research Foundation, Marshfield, Wisconsin

D. J. Reding, MD

Departments of Hematology and Oncology, Marshfield Clinic, Marshfield, Wisconsin

Brian K. Suarez, PhD

Departments of Psychiatry and Genetics, Washington University School of Medicine, St. Louis, Missouri

William J. Catalona, MD

Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri

James K. Burmester, PhD

Personalized Medicine Research Center, Marshfield Medical Research Foundation, Marshfield, Wisconsin

REPRINT REQUESTS: James K. Burmester, PhD, Personalized Medicine Research Center, Marshfield Medical Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449, Telephone: 715-389-4368, Fax: 715-389-3808, Email: burmester.james{at}marshfieldclinic.org

Prostate cancer is the most frequently diagnosed visceral cancer of men, responsible for approximately 40,000 deaths in adult males per year. To identify the genetic causes of prostate cancer, we performed a whole genome scan of affected sib pairs, using DNA markers spaced evenly across the human genome. We demonstrated that regions on chromosomes 1, 4, 5, 7, 8, 11, 16 and 19 might harbor genes that predispose individuals to prostate cancer and may affect tumor growth rate and tumor aggressiveness. Here we present DNA sequence analysis of KIAA 0872 and 17-ß hydroxysteroid dehydrogenase that are located on chromosome 16 within the mapped region, and we demonstrate that neither of these genes carries mutations in the protein coding region or their splice junction sites. These results suggest that these genes are less likely to be associated with the cause of familial prostate cancer.

Key Words: 17ß-hydroxysteroid dehydrogenase • Chromosome 16 • Whole genome scan • Mutation analysis

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